Miniaturization Improvement and Application Research of Organic Synthesis Experiments
DOI:
https://doi.org/10.54097/bd1v0e30Keywords:
Miniaturization, organic synthesis, green chemistry, undergraduate laboratory, reaction yield, chemical educationAbstract
The miniaturization of organic synthesis experiment is very beneficial for education and research laboratory. The effect on 4 main reactions has been studied here, those are esterification, aldol condensation, nucleophilic substitution, and oxidation. With the reduction of reagents from 10 - 50 mL(conventional)to 0.1 - 2.0mL(miniaturized),four comparison experiment were done on 120 students in 2 semester by miniaturized method. I gathered quantitative info on reaction yields, time efficient, reagents and students: The smaller protocol was 78.4%, the normal sized protocol was at an average of 74.6%. And it consumed 91.3% less solvent, and the cost per sample is down 68.5%. Students were more engaged and had better operations. From the results we can see that Organic synthesis miniaturization is green chemistry and undergrad lab improvement.
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